DMFa is classified as toxic to reproduction (Reproductive toxic Cat 1B per EU 1272 / 2008 EC). Further, DMFa shows toxicity towards the liver in humans. On 22nd of November 2021, the Official Journal of the European Union published Commission Regulation (EU) 2021/2030 adding an entry 76 in Annex XVII of REACH Regulation (EC) No 1907/2006 for restriction on N,N-dimethylformamide (DMFa). Further, it is also listed as a cancer-causing chemical in the California Proposition 65.